Antigenic modulation ofBordetella pertussisin continuous culture
نویسندگان
چکیده
منابع مشابه
Antigenic Modulation
Antigenic modulation (the loss of TL antigens from TL+ cells exposed to TL antibody in the absence of lytic complement) has been demonstrated in vitro. An ascites leukemia, phenotype TL.1,2,3, which modulates rapidly and completely when incubated with TL antiserum in vitro, was selected for further study of the phenomenon. Over a wide range of TL antibody concentrations modulation at 37 degrees...
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The modulation or loss of thymus-leukemia (TL) antigenicity from the surfaces of mouse RADA1 leukemia cells and normal thymocytes during incubation with TL antibody in vitro at 37 degrees C was investigated by cytotoxicity, immunofluorescence, and immunoelectron microscopy. The fate of bivalent and monovalent antibody during modulation was visualized by fluorescence microscopy. Considerable ant...
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Several types of B-cell lymphoma have been successfully treated with rituximab, and approval by the US Food and Drug Administration for use of rituximab in the treatment of rheumatoid arthritis has increased interest in targeting CD20 on B cells for other indications. Although large amounts of rituximab can be infused into humans with no apparent dose-limiting toxicity, recent evidence suggests...
متن کاملContinuous Culture
Continuous culture on mixed glucose-lactose or glucose-butyrate media inoculated with river water led to a population composed of a pseudomonad and a coliform. The glucose was used preferentially to the other carbon source, and the utilization of the secondary carbon source was greatly reduced at high growth rates. Significant amounts of acetate were excreted even though the cultures were limit...
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In the tumor dormant state, small numbers of tumor cells persist in the host without outgrowth to overt neoplasia. The cancer l i t e ra ture contains numerous reports describing recurrence of solid tumors and leukemias years after apparent successful t r ea tmen t of the pr imary neoplasia (1). These reports suggest tha t residual tumor cells can persist in a dormant s ta te during the prolong...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1983
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1983.tb00520.x